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KMID : 1138520010040020049
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Journal of Pharmacopuncture
2001 Volume.4 No. 2 p.49 ~ p.56
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Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices
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Kim Hong-Soo
Song Chun-Ho
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Abstract
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This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against $HgCl_2$-induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM $HgCl_2$ for 60 min at $37^{\circ}C$. $HgCl_2$ caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed $Na^+-K^+$-ATPase activity and ATP depletion. SbG prevented $HgCl_2$-induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. $HgCl_2$-induced inhibition of $Na^+-K^+$-ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents $HgCl_2$-induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid.
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KEYWORD
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Scutellaria baicalensis Georgi, $HgCI_2$, Membrane transport dysfunction, Rabbit renal cortical slice, PAH uptake, $Na^+-K^+-ATPase$ activity, ATP
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